Early Regenerative Treatments, A History of Platelet Rich Plasma
Regenerative Treatments represent a significant advancement in medicine. These treatments as they pertain to the field of orthopedic medicine provide both the opportunity for pain relief and improved function while “rebuilding” your own body’s healthy tissue without surgery. To understand the advances our treatments represent in Regenerative Medical Treatment, let’s take a look at the first generation of regenerative medicine – Platelet Rich Plasma or PRP.
The body’s first response to any injury is to deliver platelets from the blood stream to the site of injury. These platelets then release growth factors, cytokines, and other small proteins that jump start the repair and healing process.
Platelet-Rich Plasma (PRP) Therapy was the first cutting-edge procedure that began a new evolution in the field of orthopedic medicine by utilizing concentrated levels of the body’s own platelets and injecting these concentrated platelets directly at the site of injury or pain.
In doing so, PRP therapy has provided healing of numerous injuries and painful conditions by stimulating the body’s own natural restorative processes.
PRP has been successfully used to treat numerous painful conditions including shoulder and knee injuries, chronic plantar fasciitis, tennis elbow, golfers elbow, ankle sprains, tendonitis, and ligament sprains.
To learn more about PRP or other regenerative medicine treatments that we perform contact us today.
A Further Look into the Science of PRP
For those interested in the details of how platelets provide healing please read the following:
Platelets contain many different structures including alpha and beta granules. The main components of PRP are the alpha granules as these structures house all of the growth factors essential to the benefits of PRP. These growth factors include: transforming growth factor beta (TGFb), vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), and epithelial growth factor (EGF). TGFb acts during inflammation to help regulate cell migration and replication. VEGF is released after the inflammatory phase and stimulates angiogenesis, as well as accelerates tendon cell and type 1 collagen synthesis. PDGF is responsible for promoting mesenchymal stem cells to the area of injury.
There are also small protein structures found within the white blood cells that are also concentrated within the conventional preparation of PRP that have the potential to provide significant benefit. These white cell derived proteins are called cytokines. It should be noted that the common and clear-cut classification of cytokines as either anti-inflammatory or pro-inflammatory may be misleading. It has been determined that the net effect of whether the body reacts with an inflammatory or anti-inflammatory response is determined by the balance between pro-inflammatory cytokines and anti-inflammatory cytokines. However, treatment may not be as simple as concentrating one anti-inflammatory molecule as the net effect of one particular cytokine can be influenced considerably by the nature of the micro-environment into which the cytokines are injected, and the
presence of other cytokines, and cytokine concentrations.